Development and Application of Magnetic Resonance Techniques for Phenotyping of Cardiovascular Disease
Prof Stefan Neubauer
Head, Division of Cardiovascular Medicine,
Oxford University, United Kingdom
Time: 15 August 2017, 17:00-18:30 AEDT
Venue: AMREP Lecture Theatre, 75 Commercial Road, Melbourne, Victoria 3004
Abstract
Clinical research in this area is carried out on 1.5 and 3T Siemens MR systems at the University of Oxford Centre for Clinical Magnetic Resonance Research (link), where we employ state-of-the-art cardiovascular magnetic resonance methods to assess aspects of cardiac function and physiology currently inaccessible to conventional imaging methods. Examples include tissue characterization methods (e.g. T1 mapping), myocardial oxygenation (BOLD), 4D flow and 7 Tesla human imaging (7T system installed 9/11). We also apply established CMR techniques to study novel scientific hypotheses, e.g. in patients with cardiomyopathies, ischemic heart disease and heart valve disease. Examples include the development of diagnostic criteria for left ventricular non-compaction, perfusion abnormalities in hypertrophic cardiomyopathy, or assessment of irreversible myocardial injury associated with revascularization (PCI or CABG). Our clinical science programme is closely integrated with the clinical cardiac CMR service (link) for the ORH NHS Trust, providing a truly translational research environment.
State-of-the-art methods for experimental Magnetic Resonance Imaging and Spectroscopy, to non-invasively characterize experimental models, are being developed at the BHF experimental MR unit (BMRU), co-led by Dr Jürgen Schneider, using a 9.4T high-field Agilent MR system.
Biography
Prof. Stefan Neubauer is a Professor of Cardiovascular Medicine, Clinical Director of the Oxford Centre for Clinical Magnetic Resonance Research (OCMR), and Co-Director of the BHF Experimental MR Unit (Henry Wellcome Building of Genomic Medicine), at the Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom. Prof. Neubauer’s work over the past 25 years has been devoted to two areas, the development and application of Cardiovascular Magnetic Resonance (CMR) imaging and spectroscopy, and the role of cardiac energy metabolism in ischemia and heart failure. He has published >300 original research articles and currently leads a group of ~40 co-workers. Editorial positions andcontributions to scientific bodies include his involvement with theSociety for Cardiovascular Magnetic Resonance (President 2006-2008), Chairman of the British Society of Cardiovascular Magnetic Resonance (2008-2010), Associate Editor of the European Heart Journal and of the Journal of Cardiovascular Magnetic Resonance,Co-Editor of Magnetic Resonance Materials. Awards and Honours include the American Heart Association Paul Dudley White International Lectureship Award 2005 and the British Cardiovascular Society Thomas Lewis Lecture 2008. He is a fellow of the UK Academy of Medical Sciences. He is also the leader of the Heart Theme for the Oxford NIHR Biomedical Research Centre.